ß2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study.
J Am Soc Hypertens
; 5(2): 114-22, 2011.
Article
in En
| MEDLINE
| ID: mdl-21414566
Nondipping nocturnal blood pressure (BP) is associated with target organ damage and cardiovascular disease. We hypothesized that ß1- and ß2-AR-associated single nucleotide polymorphisms (SNPs) would associate with nondipping BP patterns. Participants (n = 497, age range 30-74 years, 40% female) of the Wisconsin Sleep Cohort Study with at least one ambulatory BP monitoring test were included. Nondipping was defined as less than a 10% dip in sleep BP compared with wake BP. Dipping ratios were calculated as sleep/wake BP. Single nucleotide polymorphisms in the ß1-AR (rs7076938, tagging for Gly389Arg) and ß2-AR (rs17778257 and rs2400707, tagging for Arg16Gly and Gln27Glu) were selected. ß2-AR SNP rs2400707 A-positive subjects (tagging for Glu27) had higher systolic and diastolic dipping ratios in a dose-response fashion. Systolic dipping ratios were: GG = 0.846; AG = 0.854; AA = 0.861 (P = .015). Diastolic dip ratios were: GG = 0.807; AG = 0.815; AA = 0.824 (P = .026). The ß2-AR rs17778257/rs2400707 A/A haplotype was associated with dipping ratios and systolic nondipping status (nondipping odds radio 2.0 [1.0-3.8] for A/A versus A/G). Results were similar when models included participants on antihypertensive medications. Higher dipping ratios indicating a lack of nocturnal BP dipping are associated with ß2-AR polymorphisms. Nocturnal dipping patterns may be modulated by ß2-AR polymorphisms.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Cardiovascular Diseases
/
Circadian Rhythm
/
Receptors, Adrenergic, beta-2
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Hypertension
Type of study:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
J Am Soc Hypertens
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Country of publication: