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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Xu, Rui; Banka, Anna; Blake, James F; Mitchell, Ian S; Wallace, Eli M; Bencsik, Josef R; Kallan, Nicholas C; Spencer, Keith L; Gloor, Susan L; Martinson, Matthew; Risom, Tyler; Gross, Stefan D; Morales, Tony H; Wu, Wen-I; Vigers, Guy P A; Brandhuber, Barbara J; Skelton, Nicholas J.
Affiliation
  • Xu R; Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, USA. rxu@arraybiopharma.com
Bioorg Med Chem Lett ; 21(8): 2335-40, 2011 Apr 15.
Article in En | MEDLINE | ID: mdl-21420856
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Sulfonamides / Cyclic AMP-Dependent Protein Kinases / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Sulfonamides / Cyclic AMP-Dependent Protein Kinases / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: Country of publication: