Knockout mouse models of iron homeostasis.
Annu Rev Nutr
; 31: 117-37, 2011 Aug 21.
Article
in En
| MEDLINE
| ID: mdl-21548776
ABSTRACT
Murine models have made valuable contributions to our understanding of iron metabolism. Investigation of mice with inherited forms of anemia has led to the discovery of novel proteins involved in iron homeostasis. A growing number of murine models are being developed to investigate mitochondrial iron metabolism. Mouse strains are available for the major forms of hereditary hemochromatosis. Findings in murine models support the concept that the pathogenesis of nearly all forms of hereditary hemochromatosis involves inappropriately low expression of hepcidin. The availability of mice with floxed iron-related genes allows the study of the in vivo consequences of cell-selective deletion of these genes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Animal
/
Disease Models, Animal
/
Homeostasis
/
Iron
/
Mice
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Annu Rev Nutr
Year:
2011
Document type:
Article
Affiliation country: