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Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Shirendeb, Ulziibat P; Calkins, Marcus J; Manczak, Maria; Anekonda, Vishwanath; Dufour, Brett; McBride, Jodi L; Mao, Peizhong; Reddy, P Hemachandra.
Affiliation
  • Shirendeb UP; Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Hum Mol Genet ; 21(2): 406-20, 2012 Jan 15.
Article in En | MEDLINE | ID: mdl-21997870
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Synapses / Nuclear Proteins / Huntington Disease / Mitochondrial Proteins / GTP Phosphohydrolases / Microtubule-Associated Proteins / Mitochondria / Mutation / Nerve Tissue Proteins Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2012 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Synapses / Nuclear Proteins / Huntington Disease / Mitochondrial Proteins / GTP Phosphohydrolases / Microtubule-Associated Proteins / Mitochondria / Mutation / Nerve Tissue Proteins Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2012 Document type: Article Affiliation country: Country of publication: