Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.
Bioorg Med Chem Lett
; 21(23): 7185-8, 2011 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-22001029
ABSTRACT
A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridazines
/
Stomach Neoplasms
/
Triazoles
/
Drug Design
/
Proto-Oncogene Proteins c-met
/
Protein Kinase Inhibitors
/
Isoquinolines
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2011
Document type:
Article