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Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
Zhang, Donglu; Flint, Oliver; Wang, Lifei; Gupta, Ashok; Westhouse, Richard A; Zhao, Weiping; Raghavan, Nirmala; Caceres-Cortes, Janet; Marathe, Punit; Shen, Guoxiang; Zhang, Yueping; Allentoff, Alban; Josephs, Jonathan; Gan, Jinping; Borzilleri, Robert; Humphreys, W Griffith.
Affiliation
  • Zhang D; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, USA.
Chem Res Toxicol ; 25(3): 556-71, 2012 Mar 19.
Article in En | MEDLINE | ID: mdl-22295996
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Cholesterol Side-Chain Cleavage Enzyme / Adrenal Glands / Protein Kinase Inhibitors Limits: Animals / Humans / Male Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Cholesterol Side-Chain Cleavage Enzyme / Adrenal Glands / Protein Kinase Inhibitors Limits: Animals / Humans / Male Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article Affiliation country: Country of publication: