Merging domino and redox chemistry: stereoselective access to di- and trisubstituted ß,γ-unsaturated acids and esters.
Chemistry
; 18(12): 3468-72, 2012 Mar 19.
Article
in En
| MEDLINE
| ID: mdl-22354501
ABSTRACT
Merging is the game! The coupling of a domino reaction and an internal neutral redox reaction constitutes an excellent manifold for the stereoselective synthesis of di- and trisubstituted olefins featuring a malonate unit, an ester, or a free carboxylic acid as substituents at the allylic position (see scheme; MW=microwave). The reaction utilizes simple starting materials (propargyl vinyl ethers), methanol or water as solvents, and a very simple and bench-friendly protocol.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carboxylic Acids
/
Alkenes
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2012
Document type:
Article
Affiliation country: