The complex regulation of TGF-ß in cardiovascular disease.
Vasc Health Risk Manag
; 8: 533-9, 2012.
Article
in En
| MEDLINE
| ID: mdl-23028232
ABSTRACT
Transforming growth factor ß (TGF-ß1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-ß1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-ß1 pathway to diagnosis and therapeutics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Cardiovascular System
/
Transforming Growth Factor beta1
Limits:
Animals
/
Humans
Language:
En
Journal:
Vasc Health Risk Manag
Journal subject:
ANGIOLOGIA
Year:
2012
Document type:
Article
Affiliation country: