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3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
Soth, Michael; Hermann, Johannes C; Yee, Calvin; Alam, Muzaffar; Barnett, Jim W; Berry, Pamela; Browner, Michelle F; Frank, Karl; Frauchiger, Sandra; Harris, Seth; He, Yang; Hekmat-Nejad, Mohammad; Hendricks, Than; Henningsen, Robert; Hilgenkamp, Ramona; Ho, Hoangdung; Hoffman, Ann; Hsu, Pei-Yuan; Hu, Dong-Qing; Itano, Andrea; Jaime-Figueroa, Saul; Jahangir, Alam; Jin, Sue; Kuglstatter, Andreas; Kutach, Alan K; Liao, Cheng; Lynch, Stephen; Menke, John; Niu, Linghao; Patel, Vaishali; Railkar, Aruna; Roy, Douglas; Shao, Ada; Shaw, David; Steiner, Sandra; Sun, Yongliang; Tan, Seng-Lai; Wang, Sandra; Vu, Minh Diem.
Affiliation
  • Soth M; Hoffmann-La Roche, 340 Kingsland Street, Nutley, New Jersey 07110, USA. michael.soth@roche.com
J Med Chem ; 56(1): 345-56, 2013 Jan 10.
Article in En | MEDLINE | ID: mdl-23214979
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyrroles / Anti-Inflammatory Agents, Non-Steroidal / Cyclopropanes / Janus Kinase 1 / Janus Kinase 3 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyrroles / Anti-Inflammatory Agents, Non-Steroidal / Cyclopropanes / Janus Kinase 1 / Janus Kinase 3 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Country of publication: