Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: comparison of RECIST, Choi and volumetric criteria.
Eur J Radiol
; 82(6): 951-8, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23518148
ABSTRACT
PURPOSE:
Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). PATIENTS ANDMETHODS:
20 patients (mean 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan-Meier statistics.RESULTS:
The mean DSS (in months) of the response groups 3 months after therapy change was RECIST PR (0/20); SD (17/20) 30.4 (months); PD (3/20) 11.6. Choi PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS RECIST PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3.CONCLUSION:
One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritoneal Neoplasms
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Pyrroles
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Radiographic Image Interpretation, Computer-Assisted
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Tomography, X-Ray Computed
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Imaging, Three-Dimensional
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Gastrointestinal Stromal Tumors
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Indoles
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Liver Neoplasms
Type of study:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Eur J Radiol
Year:
2013
Document type:
Article
Affiliation country: