Final height in congenital adrenal hyperplasia: the dilemma of hypercortisolism versus hyperandrogenism.
Arq Bras Endocrinol Metabol
; 57(2): 126-31, 2013 Mar.
Article
in En
| MEDLINE
| ID: mdl-23525290
ABSTRACT
OBJECTIVE:
The purpose of this study was to identify factors that might interfere with reaching the final height in patients with 21-hydroxylase deficiency (21-OHD). SUBJECTS ANDMETHODS:
Thirty-one patients with classical 21-OHD who reached their FH in our Institution were evaluated in order to compare the Z score for final height (FHZ) with (1) the target height, (2) the standard height for the population, and (3) the hydrocortisone treatment schedule.RESULTS:
The FHZ of -2.13 ± 1.11 had a significant negative correlation with the hydrocortisone doses used throughout the period of study. Patients who reached FH within the normal population range were those who received lower doses of hydrocortisone, as compared to those whose FH remained below -2 SDS.CONCLUSION:
We conclude that careful treatment adjustments have a major influence on growth of children with CAH, and that the dose range for hydrocortisone replacement that does not lead to side effects is relatively narrow. The better height outcome was achieved in 21-OHD patients who received lower doses of hydrocortisone.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Height
/
Hydrocortisone
/
Adrenal Hyperplasia, Congenital
Type of study:
Prognostic_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
Arq Bras Endocrinol Metabol
Year:
2013
Document type:
Article
Affiliation country: