Biological active analogues of the opioid peptide biphalin: mixed α/ß(3)-peptides.
J Med Chem
; 56(8): 3419-23, 2013 Apr 25.
Article
in En
| MEDLINE
| ID: mdl-23547584
ABSTRACT
Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding homo-ß(3) amino acids. The derivative 1 containing hß(3) Phe in place of Phe showed good µ- and δ-receptor affinities (Ki(δ) = 0.72 nM; Ki(µ) = 1.1 nM) and antinociceptive activity in vivo together with an increased enzymatic stability in human plasma.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enkephalins
Limits:
Animals
/
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2013
Document type:
Article
Affiliation country: