Overexpression of TNF-&#945; in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria.

Vattemi, Gaetano; Marini, Matteo; Ferreri, Nicholas R; Hao, Shoujin; Malatesta, Manuela; Meneguzzi, Alessandra; Guglielmi, Valeria; Fava, Cristiano; Minuz, Pietro; Tomelleri, Giuliano

Overexpression of TNF-α in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria.

Vattemi, Gaetano; Marini, Matteo; Ferreri, Nicholas R; Hao, Shoujin; Malatesta, Manuela; Meneguzzi, Alessandra; Guglielmi, Valeria; Fava, Cristiano; Minuz, Pietro; Tomelleri, Giuliano.

Affiliation

Vattemi G; Section of Clinical Neurology, Department of Neurological, Neuropsychological, Morphological, and Movement Sciences, University of Verona, 37134 Verona, Italy. gaetano.vattemi@univr.it

Free Radic Biol Med ; 63: 108-14, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23619127

Subject(s)
Key words

COX; CPEO; Chronic progressive external ophthalmoplegia; Cytochrome c oxidase; Free radicals; MD; MELAS; MERRF; Mitochondria; Mitochondrial disease; Mitochondrial diseases; Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes; Myoclonic epilepsy with ragged red fibers; OXPHOS; Oxidative phosphorylation; Quantitative real-time PCR; ROS; Reactive oxygen species; SDH; Succinate dehydrogenase; TNF receptor type 1; TNF receptor type 2; TNF-α; TNFR1; TNFR2; Tumor necrosis factor-α; qRT-PCR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Mitochondrial Diseases / Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II Limits: Female / Humans / Male Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2013 Document type: Article Affiliation country: Country of publication:

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