Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells.
J Virol
; 87(16): 9373-8, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23760252
ABSTRACT
Lentivirus infection activates CD4(+) CD25(+) T regulatory (Treg) cells. Activation of Treg cells may be due to direct virus infection or chronic antigenic stimulation. Herein we demonstrate that in vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor ß (TGF-ß). These data demonstrate for the first time that AIDS lentiviruses infect and activate Treg cells, potentially contributing to immune dysfunction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CD4-Positive T-Lymphocytes
/
T-Lymphocyte Subsets
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Immunosuppression Therapy
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T-Lymphocytes, Regulatory
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Immunodeficiency Virus, Feline
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2013
Document type:
Article
Affiliation country: