Effects of biological sex on the pathophysiology of the heart.
Br J Pharmacol
; 171(3): 555-66, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-23763376
ABSTRACT
Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex-specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Cardiovascular Diseases
/
Heart
/
Models, Biological
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Br J Pharmacol
Year:
2014
Document type:
Article
Affiliation country: