Simultaneous integrated boost-intensity-modulated radiotherapy in head and neck cancer.
Laryngoscope
; 123(12): E97-103, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-23775348
ABSTRACT
OBJECTIVES/HYPOTHESIS:
To review toxicity and outcomes in patients with head and neck cancer treated with simultaneous integrated boost-intensity-modulated radiotherapy (SIB-IMRT). STUDYDESIGN:
Review of experience with the SIB-IMRT technique.METHODS:
Fifty patients were treated with the SIB-IMRT technique. Two possible schedules of radiation therapy (RT) were used SIB 70 (70/60/54 in 33 fractions) and SIB 66 (66/60/54 in 33 fractions). Forty-one patients also received chemotherapy.RESULTS:
All but two patients completed treatment as prescribed. No G4 acute toxicity has been reported in our series. We did not observe any G3 to G4 chronic toxicity, apart from one case of cutaneous necrosis. After a median follow-up of 23.3 months (range, 1-60 months), 41 patients (82%) were alive and negative for disease, and one patient (2%) was alive with distant metastases. Eight patients (16%) died, seven because of progressive disease and one for other causes.CONCLUSIONS:
SIB-IMRT is a highly effective and safe technique of RT in the treatment of head and neck cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiotherapy, Intensity-Modulated
/
Head and Neck Neoplasms
/
Antineoplastic Agents
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Laryngoscope
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2013
Document type:
Article
Affiliation country: