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Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimäki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho; Dunham, Ian; Neale, Benjamin M; Palta, Priit; Hamalainen, Eija; Schürks, Markus; Rose, Lynda M; Buring, Julie E; Ridker, Paul M; Steinberg, Stacy; Stefansson, Hreinn; Jakobsson, Finnbogi; Lawlor, Debbie A; Evans, David M; Ring, Susan M; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari A; Freilinger, Tobias; Schoenen, Jean; Frants, Rune R; Pelzer, Nadine; Weller, Claudia M; Zielman, Ronald; Heath, Andrew C; Madden, Pamela A F; Montgomery, Grant W; Martin, Nicholas G; Borck, Guntram; Göbel, Hartmut; Heinze, Axel.
Affiliation
  • Anttila V; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Winsvold BS; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Gormley P; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Kurth T; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bettella F; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • McMahon G; Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Kallela M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Malik R; INSERM Unit 708 - Neuroepidemiology, F-33000 Bordeaux, France.
  • de Vries B; University of Bordeaux, F-33000 Bordeaux, France.
  • Terwindt G; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
  • Medland SE; deCODE genetics, Reykjavik, Iceland.
  • Todt U; MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • McArdle WL; Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
  • Quaye L; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
  • Koiranen M; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
  • Ikram MA; Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Lehtimäki T; Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
  • Stam AH; Institute of Human Genetics, University of Ulm, Ulm, Germany.
  • Ligthart L; MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Wedenoja J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Dunham I; Institute of Health Sciences, University of Oulu, Oulu, Finland.
  • Neale BM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Palta P; Department of Radiology Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • Hamalainen E; Department of Neurology Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • Schürks M; Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
  • Rose LM; Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Buring JE; Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
  • Ridker PM; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
  • Steinberg S; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
  • Stefansson H; European Bioinformatics Insitute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Jakobsson F; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Lawlor DA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Evans DM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Ring SM; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Färkkilä M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Artto V; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Kaunisto MA; Department of Neurology, University Hospital Essen, Essen, Germany.
  • Freilinger T; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
  • Schoenen J; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
  • Frants RR; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
  • Pelzer N; Harvard Medical School, Boston, MA 02215, USA.
  • Weller CM; deCODE genetics, Reykjavik, Iceland.
  • Zielman R; deCODE genetics, Reykjavik, Iceland.
  • Heath AC; Department of Neurology, Landspitali University Hospital, Reykjavik, Iceland.
  • Madden PAF; MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Montgomery GW; MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Martin NG; MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Borck G; Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
  • Göbel H; Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
  • Heinze A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Nat Genet ; 45(8): 912-917, 2013 Aug.
Article in En | MEDLINE | ID: mdl-23793025
ABSTRACT
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genome-Wide Association Study / Genetic Loci / Migraine Disorders Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2013 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genome-Wide Association Study / Genetic Loci / Migraine Disorders Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: