Predictors of methamphetamine psychosis: history of ADHD-relevant childhood behaviors and drug exposure.
Psychiatry Res
; 210(2): 529-35, 2013 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-23896355
The goal of this study was to extend our previous research that reported a significant association between Attention Deficit Hyperactivity Disorder (ADHD)-relevant childhood behaviors and the frequency of methamphetamine (MA)-induced psychotic symptoms in an expanded sample. 190 participants who met DSM-IV criteria for MA dependence were administered the Methamphetamine Experience Questionnaire that assessed MA-induced psychosis. Data related to MA exposure, comorbid drug use, education, familial psychiatric history and assessments of ADHD-relevant childhood behaviors as measured by the Wender Utah Rating Scale (WURS) were collected. Although WURS scores did not differ between 145 MAP+ and 45 MAP- subjects, MAP+ subjects with higher WURS scores were significantly more likely to report more frequent psychosis. Although mean daily MA dosage did not differ between the MAP+ and MAP- subjects, MAP+ subjects who consumed larger doses of MA were significantly more likely to experience frequent psychosis. These data suggest that ADHD-relevant childhood behaviors may interact with MA exposure to reflect a neurobiological vulnerability related to the emergence of frequent MA-induced psychotic symptoms. These results may elucidate factors that contribute to the psychiatric sequelae of MA abuse.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychoses, Substance-Induced
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Attention Deficit Disorder with Hyperactivity
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Amphetamine-Related Disorders
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Central Nervous System Stimulants
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Methamphetamine
Type of study:
Diagnostic_studies
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Psychiatry Res
Year:
2013
Document type:
Article
Country of publication: