Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases.
Transfus Apher Sci
; 49(3): 644-6, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-23899959
ABSTRACT
Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura share presentations, therapies and diagnostic evaluation of activity of the metalloprotease ADAMTS13. Here, we report a patient with the clinical presentation of thrombotic microangiopathic thrombocytopenia, normal ADAMTS13, prolonged regimen of therapeutic plasma exchanges (TPEs), bone marrow biopsy showing adequate tri-lineage hematopoiesis, and low immature platelet fraction (%-IPF) (<1.0%). Low %-IPF suggested platelet hypoproduction; high steroid therapy, in conjunction with TPEs, resulted in the recovery of platelet count. Further investigation is needed to determine if %-IPF can guide therapy in cases of microangiopathic hemolytic anemias refractory to therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Platelets
/
Thrombotic Microangiopathies
/
Anemia, Hemolytic
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Transfus Apher Sci
Journal subject:
HEMATOLOGIA
Year:
2013
Document type:
Article
Affiliation country: