Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study.
Mult Scler
; 19(11): 1508-17, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-24014572
ABSTRACT
BACKGROUND:
Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS).OBJECTIVES:
The CoSMo study evaluated the association between CCSVI and MS.METHODS:
The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded.RESULTS:
The study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers.CONCLUSIONS:
CCSVI is not associated with MS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord
/
Venous Insufficiency
/
Brain
/
Multiple Sclerosis
Type of study:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
Limits:
Adult
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Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2013
Document type:
Article
Affiliation country: