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Non-contact lens use-related Acanthamoeba keratitis in southern Turkey: evaluation of risk factors and clinical features.
Erdem, Elif; Evcil, Yusuf; Yagmur, Meltem; Eroglu, Fadime; Koltas, Soner; Ersoz, Reha.
Affiliation
  • Erdem E; 1 Ophthalmology Department, Cukurova University Faculty of Medicine, Adana - Turkey.
Eur J Ophthalmol ; 24(2): 164-72, 2014.
Article in En | MEDLINE | ID: mdl-24030538
PURPOSE: To assess the diagnostic methods, risk factors, and clinical features of Acanthamoeba keratitis cases in patients who do not wear contact lenses. METHODS: Medical records of 26 consecutive patients with non-contact lens-related Acanthamoeba keratitis, who were followed up at the tertiary eye care center between May 2010 and May 2012, were analyzed. Laboratory, demographic, and clinical findings were evaluated pertaining to the patients. RESULTS: Twenty-six non-contact lens-related Acanthamoeba keratitis cases were included in the study. The main risk factors were trauma (group 1, n = 13 patients) and ocular surface disease (group 2, n = 12 patients). One patient had both of the risk factors mentioned above. Overall test results showed that Acanthamoeba positivity rates were 15.3% for direct microscopy, 46.1% for culture, 92.3% for conventional polymerase chain reaction (PCR), and 100% for real-time PCR. The rates of full-thickness corneal involvement and ring-shaped infiltrations were higher in group 2, whereas superficial keratitis and radial keratoneuritis were higher in group 1. The final visual acuities were significantly better in group 1 than group 2 (p<0.025). CONCLUSIONS: This study is the first regional report from Turkey about Acanthamoeba keratitis in non-contact lens users. A majority of cases admitted to a tertiary eye care center were related to trauma or ocular surface disease. Physician suspicion is critically important for the timely diagnosis of these cases. At this point, molecular diagnostic tests (PCR or real-time PCR) seem to support the clinical diagnosis of Acanthamoeba keratitis with the help of fast and reliable results.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acanthamoeba / Acanthamoeba Keratitis / Contact Lenses Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Eur J Ophthalmol Journal subject: OFTALMOLOGIA Year: 2014 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acanthamoeba / Acanthamoeba Keratitis / Contact Lenses Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Eur J Ophthalmol Journal subject: OFTALMOLOGIA Year: 2014 Document type: Article Country of publication: