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Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation.
Koido, Shigeo; Homma, Sadamu; Okamoto, Masato; Namiki, Yoshihisa; Kan, Shin; Takakura, Kazuki; Kajihara, Mikio; Uchiyama, Kan; Hara, Eiich; Ohkusa, Toshifumi; Gong, Jianlin; Tajiri, Hisao.
Affiliation
  • Koido S; Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan ; Institute of Clinical Medicine and Research; The Jikei University School of Medicine; Tokyo, Japan ; Department of Oncology; Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, Japan.
Oncoimmunology ; 2(8): e25375, 2013 Aug 01.
Article in En | MEDLINE | ID: mdl-24167764
ABSTRACT
Tumor-derived transforming growth factor ß1 (TGFß1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFß1 blockade and the production of interleukin-12.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncoimmunology Year: 2013 Document type: Article Affiliation country:
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Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncoimmunology Year: 2013 Document type: Article Affiliation country: