Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation.
Oncoimmunology
; 2(8): e25375, 2013 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-24167764
ABSTRACT
Tumor-derived transforming growth factor ß1 (TGFß1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFß1 blockade and the production of interleukin-12.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Oncoimmunology
Year:
2013
Document type:
Article
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