The influence of serum sodium concentration on prognosis in resected non-small cell lung cancer.
Thorac Cardiovasc Surg
; 62(4): 338-43, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24297635
ABSTRACT
BACKGROUND:
Hyponatremia is the most common electrolyte disorder and is a negative prognostic factor in several kinds of cancer. However, few reports have referred to hyponatremia in non-small cell lung cancer (NSCLC). In the present study, the authors examined the influence of preoperative serum sodium concentration on survival in completely resected NSCLC.METHODS:
A total of 386 completely resected NSCLC patients were retrospectively analyzed.RESULTS:
Kaplan-Meier survival curves showed that serum sodium concentration was a significant prognostic factor, and the log-rank statistical value was maximum (9.173, p = 0.002) when the cutoff value of serum sodium concentration was 139 mEq/L. The overall 5-year survival rate of the high-serum sodium concentration group (> 139 mEq/L) was 74.8% and that of the low-serum sodium concentration group (≤ 139 mEq/L) was 59.7%. Clinicopathological factors showed significant differences between the two groups for leukocyte count, neutrophil count, C-reactive protein, tumor size, and pleural invasion.CONCLUSIONS:
Low-serum sodium concentration, which was associated with tumor status and inflammation, had negative prognostic influence in completely resected NSCLC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonectomy
/
Sodium
/
Carcinoma, Non-Small-Cell Lung
/
Hyponatremia
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Lung Neoplasms
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Thorac Cardiovasc Surg
Year:
2014
Document type:
Article
Affiliation country: