8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.

Carbain, Benoit; Paterson, David J; Anscombe, Elizabeth; Campbell, Allyson J; Cano, Celine; Echalier, Aude; Endicott, Jane A; Golding, Bernard T; Haggerty, Karen; Hardcastle, Ian R; Jewsbury, Philip J; Newell, David R; Noble, Martin E M; Roche, Celine; Wang, Lan Z; Griffin, Roger J

Carbain, Benoit; Paterson, David J; Anscombe, Elizabeth; Campbell, Allyson J; Cano, Celine; Echalier, Aude; Endicott, Jane A; Golding, Bernard T; Haggerty, Karen; Hardcastle, Ian R; Jewsbury, Philip J; Newell, David R; Noble, Martin E M; Roche, Celine; Wang, Lan Z; Griffin, Roger J.

Affiliation

Carbain B; Department of Biochemistry, University of Oxford , South Parks Road, Oxford OX1 3QU, U.K.

J Med Chem ; 57(1): 56-70, 2014 Jan 09.

Article in En | MEDLINE | ID: mdl-24304238

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / Cyclin-Dependent Kinase 2 Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Country of publication:

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