Is leptin a predictive factor in patients with lung cancer?

OBJECTIVES: The aim of this study was to evaluate the expression and clinical significance of leptin in lung cancer. METHODS: 126 patients with lung cancer ranged from 30 to 83years of age were studied. Serum leptin levels were determined by ELISA. The mRNA and protein levels of leptin in normal and lung cancer tissues were measured by RT-PCR and immunohistochemistry. The relationships between leptin levels and clinicopathological factors were evaluated by Wilcoxon rank sum or Kruskal-Wallis H test. RESULTS: Serum leptin levels in lung cancer patients were significantly higher compared to those in controls and leptin expression in lung cancer tissue was markedly increased than that in normal lung tissue (both P<0.050). CONCLUSIONS: Determination of leptin levels might provide useful predictive information for lung cancer.