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The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
Tanimura, Natsuko; Saitoh, Shin-Ichiroh; Ohto, Umeharu; Akashi-Takamura, Sachiko; Fujimoto, Yukari; Fukase, Koichi; Shimizu, Toshiyuki; Miyake, Kensuke.
Affiliation
  • Tanimura N; Division of Innate Immunity, Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan Japan Society for the Promotion of Science, Tokyo 102-8472, Japan natsuko@ims.u-tokyo.ac.jp.
  • Saitoh S; Division of Innate Immunity, Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan.
  • Ohto U; The Graduate School of Pharmaceutical Science, University of Tokyo, Tokyo 113-8654, Japan.
  • Akashi-Takamura S; Division of Innate Immunity, Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan.
  • Fujimoto Y; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.
  • Fukase K; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.
  • Shimizu T; The Graduate School of Pharmaceutical Science, University of Tokyo, Tokyo 113-8654, Japan.
  • Miyake K; Division of Innate Immunity, Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan.
Int Immunol ; 26(6): 307-14, 2014 Jun.
Article in En | MEDLINE | ID: mdl-24380872

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Cell Membrane / Lymphocyte Antigen 96 / Toll-Like Receptor 4 / Lipid A Limits: Animals Language: En Journal: Int Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Cell Membrane / Lymphocyte Antigen 96 / Toll-Like Receptor 4 / Lipid A Limits: Animals Language: En Journal: Int Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: Country of publication: