Effects of oral ingestion of the elemental diet in patients with painful chronic pancreatitis in the real-life setting in Japan.
Pancreas
; 43(3): 451-7, 2014 Apr.
Article
in En
| MEDLINE
| ID: mdl-24622078
ABSTRACT
OBJECTIVE:
Most patients with chronic pancreatitis develop intractable abdominal pain and malnutrition. A low-fat diet is one of the options used to manage intractable abdominal pain and malnutrition. However, few reports have examined the pain-suppression effect. To investigate the effects of oral ingestion of a low-fat elemental diet composed of purified amino acids on pain and nutritional status in patients with chronic pancreatitis, a multicenter prospective study was conducted.METHODS:
Patients with chronic pancreatitis with symptoms of abdominal pain were enrolled. In addition to meals, patients ingested a low-fat elemental diet composed of purified amino acids for 12 weeks. Before and after treatment, patients were asked to indicate their pain grade using a 100-mm horizontal visual analog scale, and nutritional indices, including body mass index and blood levels of pancreatic enzymes, were measured.RESULTS:
A total of 596 patients were eligible for analysis. Marked pain reduction was observed with a significant decrease of the mean visual analog scale score by 32.9 mm from 52.9 mm after 12 weeks (P < 0.001). There were also significant improvements in nutritional indices.CONCLUSIONS:
An oral low-fat elemental diet composed of purified amino acids, which requires no special treatment procedures, may improve patients' quality of life.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Food, Formulated
/
Abdominal Pain
/
Diet, Fat-Restricted
/
Pancreatitis, Chronic
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Pancreas
Journal subject:
GASTROENTEROLOGIA
Year:
2014
Document type:
Article
Affiliation country: