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Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.
Shaw, Stevan; Bourne, Tim; Meier, Chris; Carrington, Bruce; Gelinas, Rich; Henry, Alistair; Popplewell, Andrew; Adams, Ralph; Baker, Terry; Rapecki, Steve; Marshall, Diane; Moore, Adrian; Neale, Helen; Lawson, Alastair.
Affiliation
  • Shaw S; UCB Pharma; Berkshire, UK.
  • Bourne T; UCB Pharma; Berkshire, UK.
  • Meier C; UCB Pharma; Berkshire, UK.
  • Carrington B; UCB Pharma; Berkshire, UK.
  • Gelinas R; Institute for Systems Biology; Seattle, WA USA.
  • Henry A; UCB Pharma; Berkshire, UK.
  • Popplewell A; UCB Pharma; Berkshire, UK.
  • Adams R; UCB Pharma; Berkshire, UK.
  • Baker T; UCB Pharma; Berkshire, UK.
  • Rapecki S; UCB Pharma; Berkshire, UK.
  • Marshall D; UCB Pharma; Berkshire, UK.
  • Moore A; UCB Pharma; Berkshire, UK.
  • Neale H; UCB Pharma; Berkshire, UK.
  • Lawson A; UCB Pharma; Berkshire, UK.
MAbs ; 6(3): 774-82, 2014.
Article in En | MEDLINE | ID: mdl-24670876
ABSTRACT
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-6 / Cytokine Receptor gp130 / Antibodies, Neutralizing / Antibodies, Monoclonal, Humanized Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-6 / Cytokine Receptor gp130 / Antibodies, Neutralizing / Antibodies, Monoclonal, Humanized Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: