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Squalene synthase as a target for Chagas disease therapeutics.
Shang, Na; Li, Qian; Ko, Tzu-Ping; Chan, Hsiu-Chien; Li, Jikun; Zheng, Yingying; Huang, Chun-Hsiang; Ren, Feifei; Chen, Chun-Chi; Zhu, Zhen; Galizzi, Melina; Li, Zhu-Hong; Rodrigues-Poveda, Carlos A; Gonzalez-Pacanowska, Dolores; Veiga-Santos, Phercyles; de Carvalho, Tecia Maria Ulisses; de Souza, Wanderley; Urbina, Julio A; Wang, Andrew H-J; Docampo, Roberto; Li, Kai; Liu, Yi-Liang; Oldfield, Eric; Guo, Rey-Ting.
Affiliation
  • Shang N; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Li Q; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
  • Ko TP; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
  • Chan HC; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Li J; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
  • Zheng Y; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Huang CH; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Ren F; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Chen CC; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Zhu Z; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
  • Galizzi M; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.
  • Li ZH; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.
  • Rodrigues-Poveda CA; Instituto de Parasitología y Biomedicina "Lopez-Neyra", Consejo Superior de Investigaciones Cientificas, Granada, Spain.
  • Gonzalez-Pacanowska D; Instituto de Parasitología y Biomedicina "Lopez-Neyra", Consejo Superior de Investigaciones Cientificas, Granada, Spain.
  • Veiga-Santos P; Laboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro,
  • de Carvalho TM; Laboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro,
  • de Souza W; Laboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro,
  • Urbina JA; Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela.
  • Wang AH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
  • Docampo R; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.
  • Li K; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
  • Liu YL; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
  • Oldfield E; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
  • Guo RT; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
PLoS Pathog ; 10(5): e1004114, 2014 May.
Article in En | MEDLINE | ID: mdl-24789335
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Farnesyl-Diphosphate Farnesyltransferase / Trypanocidal Agents / Chagas Disease / Enzyme Inhibitors / Molecular Targeted Therapy Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2014 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Farnesyl-Diphosphate Farnesyltransferase / Trypanocidal Agents / Chagas Disease / Enzyme Inhibitors / Molecular Targeted Therapy Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2014 Document type: Article Affiliation country: Country of publication: