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Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial.
Brunner, Hermine I; Ruperto, Nicolino; Zuber, Zbigniew; Keane, Caroline; Harari, Olivier; Kenwright, Andrew; Lu, Peng; Cuttica, Ruben; Keltsev, Vladimir; Xavier, Ricardo M; Calvo, Inmaculada; Nikishina, Irina; Rubio-Pérez, Nadina; Alexeeva, Ekaterina; Chasnyk, Vyacheslav; Horneff, Gerd; Opoka-Winiarska, Violetta; Quartier, Pierre; Silva, Clovis A; Silverman, Earl; Spindler, Alberto; Baildam, Eileen; Gámir, M Luz; Martin, Alan; Rietschel, Christoph; Siri, Daniel; Smolewska, Elzbieta; Lovell, Daniel; Martini, Alberto; De Benedetti, Fabrizio.
Affiliation
  • Brunner HI; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, PRCSG Coordinating Center, Cincinnati, Ohio, USA.
  • Ruperto N; Istituto Giannina Gaslini, Pediatria II, Reumatologia, PRINTO Coordinating Centre, Genoa, Italy.
  • Zuber Z; Department of Pediatric Neurology and Rheumatology, St. Louis Children's Hospital, Cracow, Poland.
  • Keane C; Roche Products Ltd, Welwyn Garden City, UK.
  • Harari O; Roche Products Ltd, Welwyn Garden City, UK.
  • Kenwright A; Roche Products Ltd, Welwyn Garden City, UK.
  • Lu P; Roche, Nutley, New Jersey, USA.
  • Cuttica R; Hospital General de Niños Pedro de Elizalde, Buenos Aires, Argentina.
  • Keltsev V; Department of Pediatric Cardiology and Rheumatology, Samara Regional Clinical Hospital, Samara, Russia.
  • Xavier RM; Rheumatology Service, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Calvo I; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain.
  • Nikishina I; Pediatric Department, Federal State Budgetary Institution (Research Institute of Rheumatology named after V.A. Nasonova) under the Russian Academy of Medical Sciences, Moscow, Russia.
  • Rubio-Pérez N; Department of Pediatrics, Hospital Universitario, Universidad Autónoma de Nuevo León, Nuevo León, Mexico.
  • Alexeeva E; Scientific Center, Children's Health of RAMS and IM Sechenov First Moscow State Medical University, Moscow, Russia.
  • Chasnyk V; St Petersburg State Pediatric Medical Academy, St Petersburg, Russia.
  • Horneff G; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, Germany.
  • Opoka-Winiarska V; Department of Pediatric Pulmonology and Rheumatology, Medical University of Lublin, Lublin, Poland.
  • Quartier P; Unité d'Immunologie, Hématologie et Rhumatologie Pediatrique, Université Paris-Descartes, Hôpital Necker-Enfants Malades and Institut IMAGINE, Paris, France.
  • Silva CA; Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Children's Institute, São Paulo, Brazil.
  • Silverman E; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
  • Spindler A; Department of Medicine, Universidad Nacional de Tucumán, Tucumán, Argentina.
  • Baildam E; Department of Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, UK.
  • Gámir ML; Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Martin A; Tulsa Bone & Joint Associates, Tulsa, Oklahoma, USA.
  • Rietschel C; Clementine Kinderhospital, Verein Frankfurter Stiftungskrankenhäuser, Frankfurt, Germany.
  • Siri D; CAICI Institute, Rosario, Argentina.
  • Smolewska E; Department of Pediatric Cardiology and Rheumatology, Medical University of Lódz, Lódz, Poland.
  • Lovell D; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, PRCSG Coordinating Center, Cincinnati, Ohio, USA.
  • Martini A; Istituto Giannina Gaslini, Pediatria II, Reumatologia, PRINTO Coordinating Centre, Genoa, Italy Dipartimento di Pediatria, Università di Genova, Genoa, Italy.
  • De Benedetti F; Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Ann Rheum Dis ; 74(6): 1110-7, 2015 Jun.
Article in En | MEDLINE | ID: mdl-24834925
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / Antirheumatic Agents / Receptors, Interleukin-6 / Antibodies, Monoclonal, Humanized / Maintenance Chemotherapy Type of study: Clinical_trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Ann Rheum Dis Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / Antirheumatic Agents / Receptors, Interleukin-6 / Antibodies, Monoclonal, Humanized / Maintenance Chemotherapy Type of study: Clinical_trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Ann Rheum Dis Year: 2015 Document type: Article Affiliation country: Country of publication: