The effects of dendrimer size and central metal ions on photosensitizing properties of dendrimer porphyrins.
J Drug Target
; 22(7): 610-8, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-24955617
ABSTRACT
A series of dendrimer porphyrins (G(n)DP(M); n = generation of dendrimer, n = 1-3; M = coordination metal, M = freebase, Zn, Pt) were prepared and their photosensitizing properties were compared. All G(n)DP(M) exhibited sharp absorption in organic solvents. However, the Soret absorptions of G(n)DP(M)(CO(2)H) in 10 mM phosphate buffer solution (pH = 7.4) are broader than those of G(n)DP(M) in organic solvents, indicating inhomogeneous microenvironments of the focal porphyrin derivatives. All G(3)DP(M)(CO(2)H) successfully formed globular polyion complex micelles that were uniform in size. Under dark conditions, all G(n)DP(M)(CO(2)H) showed negligible cytotoxicity. However, all samples exhibited concentration-dependent photocytotoxicity under light irradiation. In vitro photocytotoxicity as well as singlet oxygen generation revealed that G(3)DP(Zn)(CO(2)H) is the best dendritic PS of the three different dendrimer porphyrin species.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platinum
/
Zinc
/
Drug Carriers
/
Photosensitizing Agents
/
Dendrimers
/
Metalloporphyrins
Limits:
Humans
Language:
En
Journal:
J Drug Target
Journal subject:
FARMACOLOGIA
Year:
2014
Document type:
Article