C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?
Leuk Res
; 38(9): 1061-6, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-25060305
C-myc protein expression has been studied in mature B-cell lymphomas and overexpression has been associated with poor prognosis. We sought to determine the prognostic significance of c-myc protein expression in B-ALL. We found ≥ 20% c-myc expression to predict risk of persistent disease in all age groups (odds ratio 7.487, p=0.013). There was no statistically significant association between c-myc expression and risk of relapse or death in our study. Routine c-myc immunostaining may help identify higher risk patients and guide management of B-ALL. Additional studies are needed to further determine the molecular mechanisms and role of c-myc expression in B-ALL.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
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Proto-Oncogene Proteins c-myc
Type of study:
Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
Language:
En
Journal:
Leuk Res
Year:
2014
Document type:
Article
Affiliation country:
Country of publication: