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Transient exposure to a physiologically-relevant concentration of calcium confers tobramycin resistance upon sessile cells of Pseudomonas aeruginosa.
Hoyle, B D; Costerton, J W.
Affiliation
  • Hoyle BD; Department of Biological Sciences, University of Calgary, Alberta, Canada.
FEMS Microbiol Lett ; 51(3): 339-41, 1989 Aug.
Article in En | MEDLINE | ID: mdl-2511067
Sessile populations of a mucoid Pseudomonas aeruginosa isolate generated in M-56 medium of 'low' (0.02 mM) or 'high' (2.5 mM) Ca2+ were treated with tobramycin (250 micrograms.ml-1), as were biofilms exposed transiently to 'high' Ca2+ medium. Viability decreased by over 99.9% within 8 h in the 'low' and 'high' samples, while transient Ca2+ exposure was protective. Dispersed sessile bacteria were as tobramycin sensitive as planktonic bacteria.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Tobramycin / Calcium Language: En Journal: FEMS Microbiol Lett Year: 1989 Document type: Article Affiliation country: Country of publication:
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Tobramycin / Calcium Language: En Journal: FEMS Microbiol Lett Year: 1989 Document type: Article Affiliation country: Country of publication: