K2CO3-mediated synthesis of functionalised 4-substituted-2-amino-3-cyano-4H-chromenes via Michael-cyclization reactions.
Molecules
; 19(12): 19253-68, 2014 Nov 25.
Article
in En
| MEDLINE
| ID: mdl-25429557
ABSTRACT
An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K2CO3 catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Potassium
/
Benzopyrans
/
Carbonates
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2014
Document type:
Article
Affiliation country: