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Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Hine, Christopher; Harputlugil, Eylul; Zhang, Yue; Ruckenstuhl, Christoph; Lee, Byung Cheon; Brace, Lear; Longchamp, Alban; Treviño-Villarreal, Jose H; Mejia, Pedro; Ozaki, C Keith; Wang, Rui; Gladyshev, Vadim N; Madeo, Frank; Mair, William B; Mitchell, James R.
Affiliation
  • Hine C; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Harputlugil E; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Zhang Y; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ruckenstuhl C; Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria.
  • Lee BC; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Brace L; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Longchamp A; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Surgery and the Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Treviño-Villarreal JH; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Mejia P; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ozaki CK; Department of Surgery and the Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Wang R; Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.
  • Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Madeo F; Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria; BioTechMed Graz, Humboldtstrasse 50, Graz 8010, Austria.
  • Mair WB; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Mitchell JR; Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.
Cell ; 160(1-2): 132-44, 2015 Jan 15.
Article in En | MEDLINE | ID: mdl-25542313
ABSTRACT
Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elusive. In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic ischemia reperfusion injury. SAA supplementation, mTORC1 activation, or chemical/genetic CGL inhibition reduced H2S production and blocked DR-mediated stress resistance. In vitro, the mitochondrial protein SQR was required for H2S-mediated protection during nutrient/oxygen deprivation. Finally, TSP-dependent H2S production was observed in yeast, worm, fruit fly, and rodent models of DR-mediated longevity. Together, these data are consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad implications for clinical translation. PAPERFLICK
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diet / Hydrogen Sulfide Type of study: Prognostic_studies Aspects: Patient_preference Limits: Animals Language: En Journal: Cell Year: 2015 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diet / Hydrogen Sulfide Type of study: Prognostic_studies Aspects: Patient_preference Limits: Animals Language: En Journal: Cell Year: 2015 Document type: Article Affiliation country: