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Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
Winter, Jon J G; Anderson, Malcolm; Blades, Kevin; Brassington, Claire; Breeze, Alexander L; Chresta, Christine; Embrey, Kevin; Fairley, Gary; Faulder, Paul; Finlay, M Raymond V; Kettle, Jason G; Nowak, Thorsten; Overman, Ross; Patel, S Joe; Perkins, Paula; Spadola, Loredana; Tart, Jonathan; Tucker, Julie A; Wrigley, Gail.
Affiliation
  • Winter JJ; AstraZeneca , Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.
J Med Chem ; 58(5): 2265-74, 2015 Mar 12.
Article in En | MEDLINE | ID: mdl-25695162
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / SOS1 Protein / Small Molecule Libraries Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / SOS1 Protein / Small Molecule Libraries Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Country of publication: