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Characterization of binding mode of action of a blocking anti-platelet-derived growth factor (PDGF)-B monoclonal antibody, MOR8457, reveals conformational flexibility and avidity needed for PDGF-BB to bind PDGF receptor-ß.
Kuai, Jun; Mosyak, Lidia; Brooks, Jon; Cain, Michael; Carven, Gregory J; Ogawa, Shinji; Ishino, Tetsuya; Tam, May; Lavallie, Edward R; Yang, Zhiyong; Ponsel, Dirk; Rauchenberger, Robert; Arch, Robert; Pullen, Nick.
Affiliation
  • Carven GJ; ‡Scholar Rock LLC, 300 Technology Square, Cambridge, Massachusetts 02142, United States.
  • Ogawa S; §Pfizer Japan Inc., 3-22-7 Yoyogi, Shibuya, Tokyo 151-8589, Japan.
  • Ponsel D; ∥Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
  • Rauchenberger R; ⊥MorphoSys AG, Lena-Christ Strasse 48, 82152 Martinsried, Germany.
  • Arch R; ¶Takeda Pharmaceuticals International Inc., One Takeda Parkway, Deerfield, Illinois 60015, United States.
Biochemistry ; 54(10): 1918-29, 2015 Mar 17.
Article in En | MEDLINE | ID: mdl-25707433
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-sis / Antibodies, Neutralizing / Antibodies, Monoclonal Limits: Humans Language: En Journal: Biochemistry Year: 2015 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-sis / Antibodies, Neutralizing / Antibodies, Monoclonal Limits: Humans Language: En Journal: Biochemistry Year: 2015 Document type: Article Country of publication: