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Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.
Ortega-Molina, Ana; Lopez-Guadamillas, Elena; Mattison, Julie A; Mitchell, Sarah J; Muñoz-Martin, Maribel; Iglesias, Gema; Gutierrez, Vincent M; Vaughan, Kelli L; Szarowicz, Mark D; González-García, Ismael; López, Miguel; Cebrián, David; Martinez, Sonia; Pastor, Joaquin; de Cabo, Rafael; Serrano, Manuel.
Affiliation
  • Ortega-Molina A; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Lopez-Guadamillas E; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Mattison JA; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
  • Mitchell SJ; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
  • Muñoz-Martin M; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Iglesias G; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Gutierrez VM; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
  • Vaughan KL; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA; SoBran, Inc., Burtonsville, MD 20866, USA.
  • Szarowicz MD; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA; SoBran, Inc., Burtonsville, MD 20866, USA.
  • González-García I; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15782, Spain.
  • López M; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15782, Spain.
  • Cebrián D; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Martinez S; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Pastor J; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • de Cabo R; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
  • Serrano M; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: mserrano@cnio.es.
Cell Metab ; 21(4): 558-70, 2015 Apr 07.
Article in En | MEDLINE | ID: mdl-25817535
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Sulfonamides / Metabolic Syndrome / Adiposity / Phosphoinositide-3 Kinase Inhibitors / Imidazoles / Indazoles Limits: Animals Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2015 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Sulfonamides / Metabolic Syndrome / Adiposity / Phosphoinositide-3 Kinase Inhibitors / Imidazoles / Indazoles Limits: Animals Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2015 Document type: Article Affiliation country: