Methamphetamine induces DNA damage in specific regions of the female rat brain.
Clin Exp Pharmacol Physiol
; 42(6): 570-5, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25867833
ABSTRACT
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine-rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine-rich brain regions that were tested. Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Damage
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Oxidative Stress
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Corpus Striatum
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Methamphetamine
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Nucleus Accumbens
Limits:
Animals
Language:
En
Journal:
Clin Exp Pharmacol Physiol
Year:
2015
Document type:
Article
Affiliation country: