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Molecular profiling of tumour budding implicates TGFß-mediated epithelial-mesenchymal transition as a therapeutic target in oral squamous cell carcinoma.
Jensen, D H; Dabelsteen, E; Specht, L; Fiehn, A M K; Therkildsen, M H; Jønson, L; Vikesaa, J; Nielsen, F C; von Buchwald, C.
Affiliation
  • Jensen DH; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet and University of Copenhagen, Denmark.
  • Dabelsteen E; Department of Odontology, Faculty of Health, University of Copenhagen, Denmark.
  • Specht L; Department of Oncology, Rigshospitalet and University of Copenhagen, Denmark.
  • Fiehn AM; Department of Pathology, Rigshospitalet and University of Copenhagen, Denmark.
  • Therkildsen MH; Department of Pathology, Rigshospitalet and University of Copenhagen, Denmark.
  • Jønson L; Department of Genomic Medicine, Rigshospitalet and University of Copenhagen, Denmark.
  • Vikesaa J; Department of Genomic Medicine, Rigshospitalet and University of Copenhagen, Denmark.
  • Nielsen FC; Department of Genomic Medicine, Rigshospitalet and University of Copenhagen, Denmark.
  • von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet and University of Copenhagen, Denmark.
J Pathol ; 236(4): 505-16, 2015 Aug.
Article in En | MEDLINE | ID: mdl-25925492
Subject(s)
Biomarkers, Tumor/genetics; Carcinoma, Squamous Cell/genetics; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Head and Neck Neoplasms/genetics; Molecular Targeted Therapy; Mouth Neoplasms/genetics; Signal Transduction; Transforming Growth Factor beta/genetics; Antineoplastic Agents/therapeutic use; Biomarkers, Tumor/metabolism; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/mortality; Carcinoma, Squamous Cell/pathology; Disease-Free Survival; Drug Design; Epithelial-Mesenchymal Transition/drug effects; Epithelial-Mesenchymal Transition/genetics; Female; Gene Expression Profiling/methods; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Head and Neck Neoplasms/drug therapy; Head and Neck Neoplasms/metabolism; Head and Neck Neoplasms/mortality; Head and Neck Neoplasms/pathology; Humans; Immunohistochemistry; In Situ Hybridization; Kaplan-Meier Estimate; Laser Capture Microdissection; Lymphatic Metastasis; Male; MicroRNAs/genetics; MicroRNAs/metabolism; Middle Aged; Mouth Neoplasms/drug therapy; Mouth Neoplasms/metabolism; Mouth Neoplasms/mortality; Mouth Neoplasms/pathology; Oligonucleotide Array Sequence Analysis; Phenotype; Polymerase Chain Reaction; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Signal Transduction/drug effects; Signal Transduction/genetics; Squamous Cell Carcinoma of Head and Neck; Time Factors; Transforming Growth Factor beta/metabolism
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Signal Transduction / Biomarkers, Tumor / Transforming Growth Factor beta / Gene Expression Profiling / Molecular Targeted Therapy / Epithelial-Mesenchymal Transition / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Pathol Year: 2015 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Signal Transduction / Biomarkers, Tumor / Transforming Growth Factor beta / Gene Expression Profiling / Molecular Targeted Therapy / Epithelial-Mesenchymal Transition / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Pathol Year: 2015 Document type: Article Affiliation country: Country of publication: