Lesson of the month 1: Acute flecainide overdose and the potential utility of lipid emulsion therapy.
Clin Med (Lond)
; 15(3): 301-3, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-26031986
ABSTRACT
Lipid-emulsion therapy (Intralipid®) has been advocated as a potential treatment for the management of cardio-toxicity arising from lipid-soluble drugs, particularly those acting upon sodium channels. This, on the basis of a number of ex vivo studies and animal models, suggests that partitioning a drug into lipid could alter its pharmacokinetics and result in significant clinical improvements. Its subsequent use in clinical case series has been seen as confirmation of this mechanism of action. While there are undoubtedly instances where lipid emulsion therapy has been associated with a desirable outcome in humans, as described in this case report, clinicians are reminded that they should not attribute causality, on this basis alone.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipids
/
Soybean Oil
/
Flecainide
/
Drug Overdose
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Clin Med (Lond)
Journal subject:
MEDICINA
Year:
2015
Document type:
Article
Affiliation country: