Excluding T Cells: Is ß-Catenin the Full Story?

Hu-Lieskovan, Siwen; Homet Moreno, Blanca; Ribas, Antoni

Hu-Lieskovan, Siwen; Homet Moreno, Blanca; Ribas, Antoni.

Affiliation

Hu-Lieskovan S; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA.
Homet Moreno B; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Ribas A; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Surgery, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Medical and Molecular Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA. Electronic address: aribas@mednet.ucla.edu.

Cancer Cell ; 27(6): 749-50, 2015 Jun 08.

Article in En | MEDLINE | ID: mdl-26058073

ABSTRACT

Spranger and colleagues reported recently in Nature an inverse relationship between melanoma intrinsic ß-catenin signaling and intratumoral T cell infiltration, providing an explanation for potential mechanisms of T cell exclusion. Further insights are needed into the mechanisms leading to a lack of T cell infiltration of cancers and primary immune resistance.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Signal Transduction / Beta Catenin / Tumor Microenvironment / Melanoma Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Country of publication:

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