Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
Physiol Behav
; 151: 456-62, 2015 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-26222614
ABSTRACT
Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reserpine
/
Fibromyalgia
/
Adrenergic Uptake Inhibitors
/
Depression
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Physiol Behav
Year:
2015
Document type:
Article
Affiliation country: