A Versatile Organocatalytic Approach for the Synthesis of Enantioenriched gem-Difluorinated Compounds.
Chemistry
; 21(39): 13689-95, 2015 Sep 21.
Article
in En
| MEDLINE
| ID: mdl-26239866
ABSTRACT
The combination of a practical and highly enantioselective organocatalytic reaction, which allows the stereoselective introduction of a benzodithiol group, with a fluorination step, gives a new and effective strategy for the stereoselective synthesis of difluorinated building blocks. The benzodithiol group is a versatile and chameleonic group that can be further functionalized before fluorination, giving customized and tailored useful synthetic strategies. As an example of the application of this facile strategy, the effective enantioselective synthesis of difluoroarundic acid is described.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2015
Document type:
Article