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Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems.
Bektas, Özlen; Üner, Aysegül; Eliaçik, Eylem; Uz, Burak; Isik, Ayse; Etgül, Sezgin; Bozkurt, Süreyya; Haznedaroglu, Ibrahim Celalettin; Göker, Hakan; Sayinalp, Nilgün; Aksu, Salih; Demiroglu, Haluk; Özcebe, Osman Ilhami; Büyükasik, Yahya.
Affiliation
  • Bektas Ö; Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey, Phone : +90 532 543 05 75, E-mail : ozlenbektas@hotmail.com.
Turk J Haematol ; 33(2): 119-26, 2016 Jun 05.
Article in En | MEDLINE | ID: mdl-26376664
OBJECTIVE: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Patients are at risk of developing cytopenias or progression to acute myeloid leukemia. Different classifications and prognostic scoring systems have been developed. The aim of this study was to compare the different prognostic scoring systems. MATERIALS AND METHODS: One hundred and one patients who were diagnosed with primary MDS in 2003-2011 in a tertiary care university hospital's hematology department were included in the study. RESULTS: As the International Prognostic Scoring System (IPSS), World Health Organization Classification-Based Prognostic Scoring System (WPSS), MD Anderson Prognostic Scoring System (MPSS), and revised IPSS (IPSS-R) risk categories increased, leukemia-free survival and overall survival decreased (p<0.001). When the IPSS, WPSS, MPSS, and IPSS-R prognostic systems were compared by Cox regression analysis, the WPSS was the best in predicting leukemia-free survival (p<0.001), and the WPSS (p<0.001) and IPSS-R (p=0.037) were better in predicting overall survival. CONCLUSION: All 4 prognostic systems were successful in predicting overall survival and leukemia-free survival (p<0.001). The WPSS was found to be the best predictor for leukemia-free survival, while the WPSS and IPSS-R were found to be the best predictors for overall survival.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Turk J Haematol Year: 2016 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Turk J Haematol Year: 2016 Document type: Article Country of publication: