Determinants of recurrence after successful treatment of Mycobacterium avium complex lung disease.
Int J Tuberc Lung Dis
; 19(10): 1239-45, 2015 Oct.
Article
in En
| MEDLINE
| ID: mdl-26459540
ABSTRACT
BACKGROUND:
The long-term treatment outcomes of Mycobacterium avium complex (MAC) lung disease (LD) have not been adequately evaluated.OBJECTIVE:
We evaluated the determinants of microbiological recurrence after successful treatment for MAC LD.DESIGN:
The medical records of 295 MAC LD patients treated with combination chemotherapy from 2004 to 2013 were reviewed. The clinical data, microbiological study results and chest computerised tomography findings were collected for each patient.RESULTS:
Ninety-one patients who maintained negative sputum conversion during treatment and had a minimum 10-month follow-up period after treatment were included. The median duration of follow-up was 25 months. Seventy-one (78.0%) patients remained microbiologically disease-free, while 20 (22.0%) had microbiological recurrence after successful treatment. Age, sex and body mass index were not associated with microbiological recurrence. Longer intervals between initial diagnosis and administration of medication (P = 0.024), increased number of involved lobes (P = 0.033) and failure of sputum conversion within 6 months of initiating treatment (P = 0.017) were significantly associated with microbiological recurrence.CONCLUSION:
Microbiological recurrence after successful anti-MAC chemotherapy was associated with the time interval between initial diagnosis and administration of medication, number of lobes involved and time to sputum conversion during treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mycobacterium avium Complex
/
Mycobacterium avium-intracellulare Infection
/
Lung Diseases
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Tuberc Lung Dis
Year:
2015
Document type:
Article