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Watson-Crick hydrogen bonding of unlocked nucleic acids.
Langkjær, Niels; Wengel, Jesper; Pasternak, Anna.
Affiliation
  • Langkjær N; Nucleic Acid Center, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.
  • Wengel J; Nucleic Acid Center, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark. Electronic address: jwe@ifk.sdu.dk.
  • Pasternak A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland. Electronic address: apa@ibch.poznan.pl.
Bioorg Med Chem Lett ; 25(22): 5064-6, 2015 Nov 15.
Article in En | MEDLINE | ID: mdl-26497284
ABSTRACT
We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson-Crick like.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligoribonucleotides Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligoribonucleotides Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: