[Insulin-like growth factor-1 (IGF-1) - structure and the role in the human body]. / Insulinopodobny czynnik wzrostu-1 (IGF-1) - budowa i rola w organizmie czlowieka.
Pediatr Endocrinol Diabetes Metab
; 20(4): 161-9, 2015.
Article
in Pl
| MEDLINE
| ID: mdl-26615583
ABSTRACT
In the recent years, managed to broadly explore the structure and role of insulin-like growth factors type 1 and 2 (IGF1 I 2). They belong to the structure of polypeptide hormones homologous to proinsulin. They are characterized by a wide range of activities. IGF-1 is a key mediator of most tissue effects of growth hormone (GH). In addition to effects on growth processes of the body, is also an important factor for cell homeostasis, is subject to both endocrine and tissue-specific auto- and paracrine regulation. In this paper, the current, general knowledge on the structure, function and mechanism of biological effects of IGF-1 in the human body was presented. Attention was also drawn to the directions of use of IGf-1 in the treatment of other diseases than the diseases of the hypothalamic-pituitary and growth disorders in children.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin-Like Growth Factor Binding Protein 1
/
Insulin-Like Growth Factor Binding Protein 3
/
Cell Enlargement
/
Cell Proliferation
Limits:
Humans
Language:
Pl
Journal:
Pediatr Endocrinol Diabetes Metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
/
PEDIATRIA
Year:
2015
Document type:
Article