The distinct clinical features and prognosis of the CD10âºMUM1⺠and CD10â»Bcl6â»MUM1â» diffuse large B-cell lymphoma.
Sci Rep
; 6: 20465, 2016 Feb 09.
Article
in En
| MEDLINE
| ID: mdl-26857366
ABSTRACT
Using an immunohistochemistry (IHC) based method, diffuse large B-cell lymphoma (DLBCL) can be classified into germinal center B-cell (GCB) and non-GCB subtypes. However, the prognostic value of Hans algorithm was contradictory in the literature. Using IHC and fluorescence in situ hybridization, we analyzed the antibodies applied in Hans algorithm and other genetic factors in 601 DLBCL patients and prognostic value of Hans algorithm in 306 cases who were treated with chemoimmunotherapy. The results showed that patients with GCB subtype have better overall survival (OS) and progression-free survival (PFS) than non-GCB cases. However, to some extent, double positive (CD10(+)MUM1(+), DP) and triple negative (CD10(-)Bcl6(-)MUM(-), TN) showed different clinical characteristics and prognosis to others that were assigned to the same cell-of-origin group. The DP group showed similar OS (median OS both not reached, P = 0.3650) and PFS (median PFS 47.0 vs. 32.7 months, P = 0.0878) with the non-GCB group while the TN group showed similar OS (median OS both not reached, P = 0.9278) and PFS (median PFS both not reached, P = 0.9420) with the GCB group. In conclusion, Recognition of specific entities in Hans algorithm could help us to accurately predict outcome of the patients and choose the best clinical management for them.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Algorithms
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Biomarkers
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Neprilysin
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Antineoplastic Combined Chemotherapy Protocols
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Lymphoma, Large B-Cell, Diffuse
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Interferon Regulatory Factors
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Proto-Oncogene Proteins c-bcl-6
Type of study:
Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Sci Rep
Year:
2016
Document type:
Article
Affiliation country: