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Clinicopathological associations of acquired erythroblastopenia.
Gunes, Gursel; Malkan, Umit Yavuz; Yasar, Hatime Arzu; Eliacik, Eylem; Haznedaroglu, Ibrahim Celalettin; Demiroglu, Haluk; Sayinalp, Nilgun; Aksu, Salih; Etgul, Sezgin; Aslan, Tuncay; Goker, Hakan; Ozcebe, Osman Ilhami; Buyukasik, Yahya.
Affiliation
  • Gunes G; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Malkan UY; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Yasar HA; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Eliacik E; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Haznedaroglu IC; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Demiroglu H; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Sayinalp N; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Aksu S; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Etgul S; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Aslan T; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Goker H; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Ozcebe OI; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
  • Buyukasik Y; Department of Internal Medicine, Division of Hematology, School of Medicine, Hacettepe University Turkey.
Int J Clin Exp Med ; 8(12): 22515-9, 2015.
Article in En | MEDLINE | ID: mdl-26885236
INTRODUCTION: Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. BACKGROUND: Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, thymoma and pregnancy. The aim of this study is to assess the frequencies and clinical associations of AE via analyzing 12340 bone marrow samples in a retrospective manner. MATERIAL AND METHOD: Bone marrow aspirations which were obtained from patients who applied to Hacettepe University Hematology Clinic between 2002 and 2013, were analyzed retrospectively. RESULTS: Thirty four erythroblastopenia cases were found. Patients ranged in age from 16 to 80 years with a median of 38 years. Fifteen patients were men (44%) and nineteen were women (56%). In these patients, detected causes of erythroblastopenia were MDS, idiopathic pure red cell aplasia (PRCA), parvovirus infection, post chemotherapy aplasia, plasma proliferative diseases, copper deficiency due to secondary amyloidosis, fever of unknown origin, hemophagocytic syndrome, enteric fever and legionella pneumonia. We found that between those reasons the most common causes of erythroblastopenia are MDS (17.7%) and idiopathic PRCA (17.7%). DISCUSSION: As a result, erythroblastopenia in the bone marrow may be an early sign of MDS. In those AE cases possibility of being MDS must be kept in mind as it can be mistaken for PRCA. CONCLUSION: To conclude, in adults MDS without excess blast is one of the most common causes of erythroblastopenia in clinical practice and in case of erythroblastopenia the presence of MDS should be investigated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Int J Clin Exp Med Year: 2015 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Int J Clin Exp Med Year: 2015 Document type: Article Country of publication: